Transforming Structural Biology through Automated Cryo-Prep
CryoLynx-AI bridges the critical gap between AI molecular modeling (AlphaFold 3, RoseTTAFold) and experimental validation. We eliminate the 60%+ sample preparation failure rate in Cryo-EM with ultra-fast, deterministic vitrification.
>10x
Sample Throughput
<80nm
Uniform Ice Layer
92%+
Grid Yield Success
Industry Bottleneck
Manual Cryo-Prep is Breaking the AI Drug Discovery Pipeline
Despite multi-million-dollar electron microscopes and advanced AI prediction models, researchers rely on manual blotting techniques invented over 30 years ago.
Ice Thickness Variability
Manual blotting creates uneven vitreous ice thickness across grids. Ice that is too thick obscures high-resolution electron beams; ice that is too thin deforms protein structures.
Severe Throughput Limits
Laboratories process only 10-15 grids per day manually. $5M+ Cryo-TEM instruments sit idle waiting for quality samples, stalling drug discovery campaigns.
Massive Sample Waste
Over 60% of prepared grids are discarded due to air-water interface denaturation or mechanical deformation, wasting hundreds of thousands of dollars in rare proteins.
Interactive Workflow Comparison
Toggle between traditional manual plunge freezing and CryoLynx-AI automated execution.
High Failure & Blotting Artifacts
Operators manually strip filter paper across fragile copper grids. Variable humidity and contact force lead to crystalline ice formation, protein air-water interface contact, and non-reproducible grid thickness.
- Success Rate: ~25-35%
- Preparation Time: 12-15 mins per grid
- Data Integration: Manual lab notebook tracking
Proprietary Technology
Designed for the Era of AI-Driven Structural Biology
CryoLynx-AI integrates sub-millisecond thermal feedback, non-contact ultrasonic vitrification, and native digital metadata output.
Automated Vitrification
Ultra-fast micro-jet ethane quenching achieving cooling rates in excess of 10⁶ K/s to ensure amorphous, non-crystalline ice every time.
Computer-Vision Quality Check
Sub-micron optical monitoring inspects droplet spread, film thickness, and grid integrity prior to plunge immersion.
Native Metadata Pipeline
Captures temperature, humidity, and deflection metrics for direct export into cryoSPARC, RELION, and computational structure pipelines.
Continuous Robotic Handling
Low-vibration robotic loader handles multi-grid cartridges for unattended overnight preparation and high-throughput screening.
Calculate Your Facility's Productivity Gain
See how much time and budget CryoLynx-AI saves your core facility or biopharmaceutical research laboratory compared to traditional manual grid preparation.
Estimated Annual Optimization Based on CryoLynx-AI benchmarks
Time Saved / Year
416 hrs
Operator labor reduction
Reagent Waste Saved
$2.15M
Sample recovery efficiency
Grid Success Rate
28% → 94%
3.3x yield enhancement
Target Sectors
Empowering Life Sciences Across Sectors
Biopharmaceutical R&D
Accelerate Structure-Based Drug Design (SBDD). Rapidly evaluate drug-protein ligand bindings without waiting weeks for sample preparation optimization.
High-Throughput ScreeningAcademic & Core Facilities
Standardize user protocols across multi-user national facilities. Eliminate operator-dependent variability and maximize microscope utilization hours.
Multi-User StandardizationAI Model Validation
Generate standardized physical datasets to train generative biological models. Feed real-time thermodynamic metadata into structural neural networks.
Physical AI Data PipelinesBuilt by Pioneers in Instrumentation & Biophysics
CryoLynx-AI is headquartered in Houston, TX, leveraging the region's world-class medical innovation, engineering talent, and biotechnology research centers.
Our team combines deep expertise in ultra-low temperature thermal physics, precision robotics, and structural biology computational pipelines.
Dr. Juan Gonzalez Dickson
Founder & Principal Investigator
Pioneering research in automated cryogenic sample preparation and precision biophysical instrumentation. Committed to establishing U.S. leadership in next-generation scientific infrastructure.
Partnering & Collaboration
Engage with CryoLynx-AI
We are actively establishing academic pilot partnerships, biopharma early-access programs, and advisory collaborations.